Launched in 2015, Profhilo® is a novel HA preparation that is based on stable hybrid cooperative complexes of high- and low-molecular weight Hyaluronic Acid, made with an innovative thermal production process patented by IBSA.
The production process starts with a simple mixture of 32 mg of high-molecular-weight HA (1100-1400 kDa) and 32 mg of low-molecular-weight HA (80-100 kDa). The mixture is then stabilised by the abovementioned thermal process, which does not use crosslinking agents and consists of, first, a high-temperature step, followed by a low-temperature step.The result is a product that boosts both remodeling and repair processes of tissues, even when scarring has occurred. It also improves skin laxity of the face, neck, and body.
PROFHILO® is indicated for the treatment of the face and body, in particular for the treatment of the malar-zygomatic and submalar areas. An initial cycle of two sessions at 30-day intervals is recommended, followed if necessary by maintenance procedures every 2 months. However, it is suggested to evaluate the specific PROFHILO® protocol according to the patients' degree of aging.
The product shows unique characteristics, such as a high HA concentration (64 mg/2 mL), ideal manageability, optimal tissue diffusion and low viscosity, and with a predominance of fluidity over elasticity. Moreover, HyCoCos has a high biocompatibility profile.
Compared to other native HA formulations, HyCoCos show the potential for a more effective global bio remodeling performance, and the simultaneous presence of high- and low-molecular-weight hyaluronan makes it a medical device that can be used in both esthetic and regenerative medicine. As proven by the research, the hybrid complex formed by H-HA and L-HA promotes wound healing of human keratinocytes in vitro better than HA alone. Moreover, this particular combination increases the expression levels of type I and type III collagens as well as elastin.
In vitro and clinical trials have confirmed the innovative characteristics of the product. Therefore, after 3 years of marketing use, the manufacturer has reviewed the postmarketing safety data to provide a full and extensive description of the product profile.